How AI Is Changing the Cybersecurity Threat Landscape in Healthcare

Summary

AI is transforming healthcare cybersecurity, enabling faster detection and response while also increasing risk. Healthcare organisations must address ransomware, phishing, legacy systems, and connected devices with layered defences that combine AI, automation, governance, monitoring, and human oversight.

Artificial intelligence is a double-edged sword, reshaping healthcare cybersecurity, giving defenders powerful new tools while also giving attackers faster, more convincing ways to breach systems. That risk is already showing up in the data, for example, in 2025 FBI reported 642 cyber incidents affecting healthcare, up from 444 in 2024, including 460 ransomware threats and 182 data breach incidents, making health care the most targeted critical infrastructure sector that year.

Healthcare is especially exposed because it combines highly sensitive patient data, life-critical operations, legacy infrastructure, connected medical devices, and third-party dependencies. That creates a large attack surface and gives cybercriminals both financial and operational leverage, since hospitals and providers often cannot afford downtime.

642

cyber incidents affecting healthcare in 2025

444

cyber incidents in 2024, the year before

460

ransomware threats

182

data breach incidents

Why is healthcare a prime cyber target?

Healthcare organisations have access to a lot of sensitive data, including patient records, billing information, insurance details, and clinical data. This data is highly valuable in the black market and can be exploited for financial fraud or identity theft. Cybercriminals are well aware that healthcare organisations are willing to pay ransoms to regain access to their data and restore their operations.

Another important aspect is that the healthcare industry has a very complex IT infrastructure comprising outdated systems, a large number of connected devices, and third-party vendors that threat actors can exploit. Modernising and securing this environment requires healthcare IT services that address infrastructure, applications, integrations, and ongoing technology management. The pandemic also accelerated remote and telehealth services, further increasing the threat by creating more entry points for attackers.

Healthcare organisations increasingly rely on specialised healthcare software development companies to modernise applications, integrate systems, and support connected care. Hospitals, clinics, and health systems must run 24/7, since even a brief outage can disrupt healthcare workflows and put patients’ lives at risk. Often, the data is so sensitive that life and death revolve around it, making it a prime target for ransomware.

All of these factors, including high-value data, operational sensitivity, and technical complexity, make healthcare cybersecurity a uniquely challenging landscape, providing attackers with an enticing opportunity.

It also explains why cybersecurity threats in healthcare continue to grow, even as organisations invest more heavily in defence.

How AI is reshaping the attacker’s toolkit

Artificial intelligence is changing cyberattacks in a more fundamental way than simply generating phishing emails or social engineering content. It is helping threat actors accelerate entire attack operations, from vulnerability discovery and reconnaissance to exploit development and execution.

Google’s Threat Intelligence Group findings show AI appearing at nearly every stage of the attack lifecycle, making existing tactics faster, cheaper, and harder to spot.

Reconnaissance is one of the clearest examples. Attackers are using AI to rapidly pull together open-source intelligence on a target, mapping organisational hierarchies, identifying decision-makers, and even researching salary bands for specific technical roles, work that used to take a skilled analyst hours or days, now compressed dramatically.

Phishing has changed in a similar way. AI-generated lures no longer carry the awkward phrasing or cultural mismatches that used to be reliable warning signs. Attackers are using models to write hyper-personalised messages that mirror an organisation’s professional tone, and in some cases to sustain believable, multi-turn conversations with a victim to build trust before ever delivering a malicious payload.

AI is also showing up inside the malware itself. One recently identified malware family calls an AI model’s API in real time to generate the code for its next stage of attack, then compiles and runs that code directly in memory so nothing is ever written to disk, a method designed specifically to dodge traditional file-based detection. Separately, researchers found a phishing kit impersonating a major cryptocurrency exchange that showed clear signs of being built using AI app-generation tools, lowering the skill and effort needed to produce a convincing fake.

Even attackers trying to build their own “custom” attack AI tools are mostly repackaging mainstream models. One underground toolkit marketed as a purpose-built offensive AI turned out, on investigation, to simply be commercial models stitched together with open-source tooling, suggesting that building dedicated criminal AI from scratch remains harder than buying access to legitimate tools and working around their guardrails. In one particularly novel case, attackers exploited the public sharing feature built into several mainstream AI chat tools, hosting fake troubleshooting instructions that tricked victims into pasting a malicious command straight into their own terminal.

It’s worth keeping this in perspective. Even the researchers tracking this activity closely note that they have not yet seen attackers achieve breakthrough capabilities that fundamentally change the threat landscape. What has changed so far is the speed, scale, and polish with which the attack has been executed. But for a sector like healthcare, where defenders are already stretched thin, and systems are often old and hard to patch, even modest gains in attacker speed and believability matter.

AI’s growing role in healthcare cybersecurity

Advanced AI models are changing cybersecurity by improving their ability to find software vulnerabilities and, in some cases, by testing whether those vulnerabilities can actually be exploited. According to Anthropic’s research, its Mythos Preview model discovered previously unknown vulnerabilities in widely used software that had already been heavily tested for years, including a 16-year-old flaw in a popular video codec that every fuzzer and human reviewer had missed, and a 27-year-old bug in an operating system built specifically around security. Findings like these suggest AI is becoming capable of uncovering hidden weaknesses that traditional review and automated testing have consistently failed to catch.

It’s worth noting that the results came from an unreleased research model, not something available off the shelf today. However, Anthropic also found that current, generally available frontier models are already strong at identifying vulnerabilities, and it encouraged organisations to start using them now rather than waiting for more advanced versions.

That kind of capability points to AI eventually being used to proactively scan hospital systems, EHR platforms, and connected devices for weaknesses before attackers find them.

The same capabilities that help defenders find and fix vulnerabilities faster could, without the right safeguards, also help attackers move faster. While AI may support threat modelling in the future, the technology is still largely untested at scale and can introduce new vulnerabilities when embedded into operations. Faster, AI-assisted attack tools mean the gap between a vulnerability becoming known and being exploited is shrinking, which puts more pressure on hospitals to patch quickly rather than on their usual maintenance cycles.

What AI-driven attacks look like in healthcare

Healthcare organisations face many of the same AI-enabled threats as other industries, but the consequences are often more severe, since attacks can directly affect patient care and access to critical systems.

Electronic health records

Electronic health records are a prime target for cybercriminals because they contain a rich mix of personal, financial, and clinical information. AI can help attackers sift through large amounts of publicly available data, identify likely entry points, and focus their efforts on systems that may contain patient records, insurance information, billing data, or other sensitive information. Once accessed, that data can be sold, used for fraud, or leveraged in extortion schemes.

Patient portals and telehealth platforms

Patient portals, telehealth platforms, and online scheduling tools are among the healthcare software solutions organisations rely on to make care more accessible, but they have also expanded the number of systems healthcare organisations need to secure. Attackers are using AI to create more convincing phishing campaigns, automate account takeover attempts, and generate fake identities that can be used to bypass verification processes or commit fraud.

Connected medical devices

Connected medical devices present another growing concern. Infusion pumps, patient monitoring systems, imaging equipment, and other Internet of Medical Things devices often run specialised software and stay in service for years past typical replacement cycles. Given how effective AI-assisted vulnerability discovery has proven on other long-unpatched, heavily tested software, it's reasonable to expect the same capability could eventually be turned toward finding weak points across large fleets of these devices.

AI-powered impersonation

Healthcare organisations should also take the threat of AI-powered impersonation seriously. In 2024, an employee at the engineering firm Arup was tricked into wiring $25 million after joining a video call where every other "executive" on the line, including the CFO, was an AI-generated deepfake built from publicly available recordings of real company meetings. No systems were breached. The fraud worked entirely by exploiting trust in a familiar face and voice.

Healthcare hasn't yet had its own publicly confirmed version of this exact scenario, but the conditions that make it work are arguably even stronger in a hospital: urgent requests are routine, deference to senior physicians and executives is built into the culture, and the pressure to act fast on anything resembling a patient-care or emergency-payment issue is high. As voice cloning and deepfake video tools keep improving, healthcare organisations will need stronger out-of-band verification for any unusual or high-stakes request before it becomes the next case study rather than something they read about.

The common thread across all of this is that AI helps attackers scale activities that used to be slow and resource-intensive. The underlying techniques aren’t always new. What’s changing is the speed, personalisation, and volume at which they can now be carried out.

AI-powered defence for cyber attacks

As the threats to healthcare cybersecurity keep increasing with advancements in AI, it is essential to build tools that help mitigate those risks. However, building AI-driven tools is only part of the answer. According to Michael Siegel, director of Cybersecurity at MIT Sloan, AI-powered cybersecurity tools alone will not suffice. A proactive, multi-layered approach that integrates human oversight, governance frameworks, AI-driven threat simulations, and real-time intelligence sharing is what’s actually needed. For healthcare organisations weighing where to invest, that’s an important starting point: AI is a powerful addition to a security strategy, not a replacement for one.
Siegel and his team at MIT Sloan outlined three pillars that should make up a comprehensive AI defence strategy.

Automated security hygiene

This covers the routine, repetitive work that security teams have traditionally had to do by hand, things like self-healing software code, self-patching systems, continuous attack surface management, zero-trust based architecture, and self-driving trustworthy networks. Automating these tasks reduces manual workload while strengthening protection against attacks that target core system vulnerabilities. For healthcare specifically, self-patching systems and continuous attack surface management are especially relevant, given how much of the sector still runs on legacy infrastructure that's difficult to track and slow to update.

Autonomous & deceptive defence systems

Utilise autonomous and deceptive defence systems that use analytics, machine learning, and real-time data collection to learn from, identify, and counteract threats as they happen. Examples include automated moving target defence and deceptive tactics that mislead attackers about what they're actually looking at. Both approaches let security teams shift from reactive to proactive, catching and disrupting an attack while it's underway rather than cleaning up after the fact.

Augmented oversight & reporting

This pillar gives executives and security leaders real-time as well as predictive insights into what's happening and what could happen across their environment. Automated risk analysis, for example, uses AI to spot emerging threats and predict how they might affect the organisation, turning raw security data into something decision makers can actually act on.

Why all three matter together comes down to a basic asymmetry in cybersecurity that the attacker only needs one point of entry and exploitation, while the defender has to stop every entry point and remain resilient against every possible exploit. That asymmetry is especially pronounced in healthcare. Between legacy EHR systems, a sprawling number of connected medical devices, third-party vendors, and remote and telehealth access points, hospitals have far more potential entry points than most industries, which makes a layered, automated defence strategy less of a nice to have and more of a necessity.

Where healthcare cybersecurity goes from here

Cybersecurity fundamentals haven’t changed; the only thing that has changed is how quickly attacks can be planned, adapted, and executed. Attackers are still looking for weaknesses, and defenders are still responsible for protecting every potential entry point.

For healthcare organisations, the challenge is particularly acute. Health systems are usually dated and complex, creating opportunities for attackers, while the operational reality of healthcare leaves little room for downtime or disruption.

Tools such as continuous monitoring, threat detection, and automated vulnerability management can help healthcare organisations improve visibility and respond to threats more quickly. Healthcare software development services can also help organisations modernise legacy applications, strengthen integrations, and build security into new digital healthcare experiences. But technology alone cannot solve cybersecurity. Effective security still depends on strong governance, well-defined processes, and experienced teams that can assess risk and respond when incidents occur.

Strengthen healthcare cybersecurity with 10Pearls

The pace of change in healthcare cybersecurity isn’t slowing down. As new technologies create new opportunities, they also introduce new risks that organisations must understand and manage.

At 10Pearls, we work with healthcare organisations to secure critical systems, improve resilience, and navigate complex regulatory and security requirements. From cybersecurity assessments and managed security services to healthcare AI consulting services, we help organisations build security into every stage of their technology journey.

Talk to our experts about how your organisation can reduce risk, strengthen defences , and prepare for the next generation of healthcare cyber threats.

FAQs about AI in healthcare cybersecurity

What is generative AI in cybersecurity?

Generative AI refers to technology that can create content such as text, code, images, and simulations. In cybersecurity, organisations use it to support activities like threat analysis, vulnerability research, security testing, and reporting. At the same time, attackers are using the same technology to improve phishing campaigns, automate reconnaissance, and develop more convincing social engineering attacks.

Healthcare systems handle large amounts of sensitive patient information, as well as operational workflows and business functions. A cyberattack can expose patient data, disrupt critical systems, delay treatment, and risk patient safety, making cybersecurity a core healthcare priority rather than just an IT concern.

AI-powered cybersecurity services use automation, machine learning, and advanced analytics to help organisations detect threats, manage vulnerabilities, and strengthen security operations. Common use cases include threat detection, continuous monitoring, incident response, and security assessments. At 10Pearls, these capabilities are combined with cybersecurity expertise and deep experience in regulated industries such as healthcare to help organizations reduce risk and respond more effectively to emerging threats.

Healthcare is a highly regulated, data-sensitive industry, as patient care and healthcare delivery rely on this data. While security tools can automate routine tasks and help teams detect threats much faster, human expertise remains essential. The most effective approach is a human-in-the-loop model, where technology supports security teams, while people remain responsible for oversight and decision-making.

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